What are the top rated Pet Friendly Vacation Rentals in South Main?

There are a lot of options in South Main. If you plan on staying in the South Main area, consider making a reservation for a few nights at one of these properties as these have been rated the top Pet Friendly Vacation Rentals in South Main: <a href="/property/the-reside-fully-furnished-condos-medical-stays-welcome/BC-5392126" class="class="static-page-link"">The Reside Fully Furnished Condos - Medical Stays Welcome</a> <a href="/property/quality-inn-suites-nrg-park-medical-center/BC-56862" class="class="static-page-link"">Quality Inn &amp; Suites NRG Park - Medical Center</a> <a href="/property/candlewood-suites-houston-medical-center-by-ihg/BC-183562" class="class="static-page-link"">Candlewood Suites Houston Medical Center by IHG</a> <a href="/property/2-bedroom-spacious-apt-in-nrg-med-ctr-with-free-parking-and-great-amenities/HA-3214175805" class="class="static-page-link"">2-Bedroom Spacious Apt in NRG Med Ctr with Free Parking and Great Amenities</a> <a href="/property/private-room-near-med-center-nrg/HA-3213870498" class="class="static-page-link"">Private room near med center,NRG</a> <a href="/property/modern-neat-dwelling-close-to-nrg-med-center/HA-3212454987" class="class="static-page-link"">*Modern Neat Dwelling close to NRG/Med Center</a> <a href="/property/four-bdrm-home-blks-from-nrg-w-hot-tub/HA-3213260749" class="class="static-page-link"">Four BDRM Home - BLKS From NRG W/Hot tub</a> <a href="/property/luxury-3-3-5-sleeps-6-12-medical-center-nrg-minute-maid-george-brown-toyota/HA-1214022450" class="class="static-page-link"">LUXURY 3/3.5 SLEEPS 6-12! Medical Center, NRG, Minute Maid, George Brown, Toyota</a> <a href="/property/unique-love-5min-distance-to-nrg/HA-3213196764" class="class="static-page-link"">Unique Love - 5min Distance to NRG.</a> <a href="/property/charming-clover-cottage-med-center-nrg-stadium/HA-3212802150" class="class="static-page-link"">Charming Clover Cottage Med-Center &amp; NRG Stadium!</a>

How many pet-friendly vacation rentals are available in South Main on Weekendgetaways?

There are more than 52 pet-friendly rentals available on Weekendgetaways. Check prices and availability in South Main and last updated on January 2026. Check an individual property if they have restrictions on the size or numbers of pets.

Which is the best dog-friendly place to stay in South Main?

There are many dog-friendly vacation homes available in South Main. Here are the most popular pet-friendly places, ranked by their guest rating as listed in South Main: SunRise Suite Beautiful 2 BR 2 BA, NRG, Medical Center, Downtown, Free WiFi, Pool Tx Home Group - Medical Center Medical Center & NRG Stadium Rock-N-Roll

Do you have any luxury vacation homes that allow pets in or near South Main?

Most definitely! There are many luxury places to stay in South Main. Use our search filter to discover all of our luxury accommodations where pets are welcome, then choose the one that matches your taste. Sorting by price is another way to find the most expensive dog-friendly home in South Main. Though note, more expensive is not always better.